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{Seminar} @ CDS: Online: 05th April: “Algorithms for the complete resolution of human genomes”

05 Apr @ 4:00 PM -- 5:00 PM

Department of Computational and Data Sciences

Department Seminar

 

SPEAKER     :  Dr. Mikko Rautianen

TITLE            : “Algorithms for the complete resolution of human genomes”

Date & Time :  April 05, 2023, 04:00 PM.

Venue              The Seminar will be held on MICROSOFT TEAMS

 

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ABSTRACT

Recent advances in sequencing technology have enabled the complete assembly of mammalian genomes, also called telomere-to-telomere assembly. In particular, highly accurate Pacbio HiFi reads and ultralong Oxford Nanopore reads have complementary advantages: high accuracy enables resolving long, high identity repeats based on tiny amounts of variation between the copies, and ultralong reads can span exact repeats. Combining these two sequencing methods into a single hybrid assembly pipeline enables resolving complete genomes. Here, we review some algorithms and tools used in recent assemblers: multiplex de Bruijn graphs, sequence-to-graph alignment, and graph based repeat resolution used in the assembler Verkko.

 

BIOGRAPHY

Dr. Mikko Rautianen is a postdoctoral researcher at the Institute for Molecular Medicine Finland. Prior to this, Mikko was a postdoctoral researcher at the National Institutes of Health (NIH) with Dr. Adam Phillippy. Mikko develops computational methods for analysing DNA sequencing data, including tools for genome assembly. Recently, he worked as a lead author in the Telomere-to-Telomere Consortium project that provided the first complete and gapless reconstruction of a human genome. Mikko completed his PhD at Max Planck Institute for Informatics in 2020 and Bachelor’s degree in computer science at University of Helsinki in 2014.

 

Host Faculty: Dr. Chirag Jain

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                                                                             ALL ARE WELCOME

Details

Date:
05 Apr
Time:
4:00 PM -- 5:00 PM
Event Categories:
,

Venue

Online