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UID:90@cds.iisc.ac.in
DTSTART;TZID=Asia/Kolkata:20250106T113000
DTEND;TZID=Asia/Kolkata:20250106T123000
DTSTAMP:20241212T060047Z
URL:https://cds.iisc.ac.in/events/seminar-cds-102-january-06th-1130-predic
 tive-and-reproducible-dynamical-modelling-of-t-cell-plasticity/
SUMMARY:{Seminar} @ CDS: #102\, January 06th\, 11:30: "Predictive and repro
 ducible dynamical modelling of T-cell plasticity."
DESCRIPTION:Department of Computational and Data Sciences\nDepartment Semin
 ar\n\n\n\nSpeaker : Prof. Denis Thieffry\, Ecole Normale Supérieure &amp\
 ; Institut Curie\, PSL University\, France\nTitle :"Predictive and reprodu
 cible dynamical modelling of T-cell plasticity"\nDate &amp\; Time : Januar
 y 06\, 2025\, 11:30 AM\nVenue : # 102\, CDS Seminar Hall\n\n\n\nABSTRACT\n
 T-helper cells play a key role in the regulation of the immune response. D
 isregulations of their differentiation can lead to various pathological co
 nditions\, including leukemia\, persistence of other kinds of tumors\, and
  autoimmune diseases. The development and differentiation of T-helper cell
 s is controlled by a complex molecular network involving dozens of signali
 ng pathways\, transcriptional factors\, and epigenetic regulatory mechanis
 m. Mathematical modelling of such complex networks can be used to integrat
 e and verify the consistency of the available information\, and to predict
  network behavior in novel situation\, e.g.\, following (epi)genetic pertu
 rbations or therapeutical interventions. Over the last decade\, we have de
 veloped a series of discrete\, logical models accounting for the developme
 nt of T-helper cells and for their differentiation in various effector or 
 regulatory subtypes. To cope with increasing model sizes and ensure the re
 producibility of our model analyses\, we developed and combined generic co
 mputational methods and tools\, which are available from the Consortium fo
 r Logical Models and Tools website (https://github.com/colomoto). This tal
 k will provide an overview of this work with a special focus on reproducib
 ility issues and discuss current trends and challenges.\n\nBIO: Prof. Deni
 s Thieffry obtained his Ph.D. in 1993 at the Free University of Brussels\,
  under the direction of René Thomas\, and made postdocs in Mexico (UNAM\,
  1995-1997)\, Germany (MPI\, Berlin\, 1997-1998) and Belgium (Univ. Ghent\
 , 1998-2000). DT was appointed as full Professor of Bioinformatics at the 
 University of Aix-Marseille in France in 2000\, before moving to Paris in 
 2010\, to assume the position of Professor of Systems Biology at the Ecole
  Normale Supérieure (ENS). He is currently Associate Editor of the journa
 ls PLoS Computational Biology and NAR Genomics &amp\; Bioinformatics. He h
 as published over 150 articles and book chapters\, mostly in international
  journals\, proceedings and books. His current research focuses on the dyn
 amical modelling of the regulatory network controlling haematopoietic/immu
 ne cell fate specification and reprogramming\, in close collaboration with
  several experimental teams.\n\nHost Faculty: Dr. Chirag Jain\n===========
 ======================================================================\nAL
 L ARE WELCOME
CATEGORIES:Events,Talks
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