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UID:69@cds.iisc.ac.in
DTSTART;TZID=Asia/Kolkata:20240805T033000
DTEND;TZID=Asia/Kolkata:20240805T043000
DTSTAMP:20240802T084826Z
URL:https://cds.iisc.ac.in/events/seminar-serc-4th-floor-auditorium-05th-a
 ugust-protein-sequence-annotation-using-language-models/
SUMMARY:{Seminar} @ SERC : 4th Floor Auditorium : 05th August: "Protein Seq
 uence Annotation using Language Models"
DESCRIPTION:We welcome you to CDS-KIAC talk on 05 August 2024 (Monday). The
  details are as below:\n\n\n\nSpeaker: Dr. Kumaresh\, post doctoral resear
 cher\, Eddy Lab at Harvard University.\nTitle: "Protein Sequence Annotatio
 n using Language Models"\nDate and Time: August 05\, 2024\, 3:30 PM\nVenue
 : #421\, SERC Auditorium\n\n\n\nAbstract:\nProtein function inference reli
 es on annotating protein domains via sequence similarity\, often modeled t
 hrough profile Hidden Markov Models (profile HMMs)\, which capture evoluti
 onary diversity within related domains. However\, profile HMMs make strong
  simplifying independence assumptions when modeling residues in a sequence
 . Here\, we introduce PSALM (Protein Sequence Annotation with Language Mod
 els)\, a hierarchical approach that relaxes these assumptions and uses rep
 resentations of protein sequences learned by protein language models to en
 able high-sensitivity\, high-specificity residue-level protein sequence an
 notation. We validate PSALM’s performance on a curated set of "ground tr
 uth" annotations determined by a profile HMM-based method and highlight PS
 ALM as a promising alternative for protein sequence annotation.\n\nBio of 
 Speaker:\nKumaresh is a post doctoral researcher in the Eddy Lab at Harvar
 d University working on machine learning models for annotating\, understan
 ding and analyzing protein sequences. He has a PhD from Harvard University
  where he worked in systems neuroscience\, building models of decision mak
 ing and attentional switching using zebrafish as a model organism. Kumares
 h's undergraduate and Masters training is in Computer Science and Electric
 al Engineering from IIIT Bangalore and he brings this strong computational
  background to tackle complex real world biological problems.\n\n\n\nALL A
 RE WELCOME
CATEGORIES:Events,Talks
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