Department of Computational and Data Sciences
Department Seminar
Speaker : Prof. Denis Thieffry, Ecole Normale Supérieure & Institut Curie, PSL University, France
Title :”Predictive and reproducible dynamical modelling of T-cell plasticity”
Date & Time : January 06, 2025, 11:30 AM
Venue : # 102, CDS Seminar Hall
ABSTRACT
T-helper cells play a key role in the regulation of the immune response. Disregulations of their differentiation can lead to various pathological conditions, including leukemia, persistence of other kinds of tumors, and autoimmune diseases. The development and differentiation of T-helper cells is controlled by a complex molecular network involving dozens of signaling pathways, transcriptional factors, and epigenetic regulatory mechanism. Mathematical modelling of such complex networks can be used to integrate and verify the consistency of the available information, and to predict network behavior in novel situation, e.g., following (epi)genetic perturbations or therapeutical interventions. Over the last decade, we have developed a series of discrete, logical models accounting for the development of T-helper cells and for their differentiation in various effector or regulatory subtypes. To cope with increasing model sizes and ensure the reproducibility of our model analyses, we developed and combined generic computational methods and tools, which are available from the Consortium for Logical Models and Tools website (https://github.com/colomoto). This talk will provide an overview of this work with a special focus on reproducibility issues and discuss current trends and challenges.
BIO: Prof. Denis Thieffry obtained his Ph.D. in 1993 at the Free University of Brussels, under the direction of René Thomas, and made postdocs in Mexico (UNAM, 1995-1997), Germany (MPI, Berlin, 1997-1998) and Belgium (Univ. Ghent, 1998-2000). DT was appointed as full Professor of Bioinformatics at the University of Aix-Marseille in France in 2000, before moving to Paris in 2010, to assume the position of Professor of Systems Biology at the Ecole Normale Supérieure (ENS). He is currently Associate Editor of the journals PLoS Computational Biology and NAR Genomics & Bioinformatics. He has published over 150 articles and book chapters, mostly in international journals, proceedings and books. His current research focuses on the dynamical modelling of the regulatory network controlling haematopoietic/immune cell fate specification and reprogramming, in close collaboration with several experimental teams.
Host Faculty: Dr. Chirag Jain
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ALL ARE WELCOME
